Lipase: Difference between revisions
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A water molecule then donates a proton to the histidine, creating a reactive hydroxyl anion. The hydroxyl anion can then attack the carbonyl carbon of the lipid, forming another negatively charged tetrahedral intermediate which is stabilized in the oxyanion hole (Reaction 3). | A water molecule then donates a proton to the histidine, creating a reactive hydroxyl anion. The hydroxyl anion can then attack the carbonyl carbon of the lipid, forming another negatively charged tetrahedral intermediate which is stabilized in the oxyanion hole (Reaction 3). | ||
[[Image:M0218. | [[Image:M0218.stg03r.gif|center|]] | ||
Upon reformation of the carbonyl, the catalytic serine is released and monoglyceride and fatty acid monomers diffuse away (Reaction 4). | Upon reformation of the carbonyl, the catalytic serine is released and monoglyceride and fatty acid monomers diffuse away (Reaction 4). | ||
[[Image:M0218. | [[Image:M0218.stg04r.gif|center|]] | ||
== '''Inhibition of Pancreatic Lipase''' == | == '''Inhibition of Pancreatic Lipase''' == | ||