Tissue factor pathway inhibitor: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II complex with trypsin (PDB code 1tfx) comp' scene=''> '''Tissue f... |
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<StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II (grey and green) complex with trypsin (pink and yellow) and Ca+2 ion (PDB code [[1tfx]]) comp' scene=''> | |||
<StructureSection load='1tfx' size='340' side='right' caption='Human tissue factor pathway inhibitor I kunitz domai II complex with trypsin (PDB code [[1tfx]]) comp' scene=''> | |||
'''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel b sheet followed by an a helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. | '''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel b sheet followed by an a helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. | ||
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== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:39, 16 July 2015
Tissue factor pathway inhibitor (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel b sheet followed by an a helix. Kunitz I domain inhibits VIIa coagulation factor while Kunitz II domain inhibits Xa. FunctionDiseaseRelevanceStructural highlights |
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3D Structures of tissue factor pathway inhibitor3D Structures of tissue factor pathway inhibitor
Updated on 16-July-2015
1adz – hTFPI-1 kunitz domain II (mutant) – human - NMR
1irh – hTFPI-1 kunitz domain III - NMR
1tfx – hTFPI-1 kunitz domain II + trypsin
1zr0 – hTFPI-2 kunitz domain I + trypsin
4dtg – hTFPI-1 kunitz domain II + antibody
4bqd – hTFPI-1 kunitz domain I + peptide