PLC beta 3 Gq: Difference between revisions

Phospholipase C beta 3 ([http://en.wikipedia.org/wiki/PLCB3 PLC-β3]) catalyzes the hydrolysis of phosphatidylinositol 4,5 bisphosphate ([http://en.wikipedia.org/wiki/Phosphatidylinositol_4,5-bisphosphate  PIP2]) to the second messengers inositol 1,4,5-trisphosphate ([http://en.wikipedia.org/wiki/Inositol_trisphosphate IP3]) and diacylglycerol ([http://en.wikipedia.org/wiki/Diglyceride DAG])in an essential step for many physiological cascades. When the receptor is stimulated by ligand of some kind it increases exchange of guanosine diphosphate (GDP) to guanosine triphosphate (GTP) on Gαq. GTP-bound Gαq activates PLC- β3, and PLC- β3 increases up to three orders of magnitude the rate of hydrolysis of GTP by its activating G protein. This is a unique mechanism in which the PLC-β3 enzyme has the ability to terminate the Gαq protein signal in addition to being activated by it.<ref>PMID:20966218</ref> <ref>PMID:23880553</ref>