4wkf: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution==
+<StructureSection load='4wkf' size='340' side='right' caption='[[4wkf]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
-The entry 4wkf is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4wkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WKF FirstGlance]. <br>
-Authors: Fadel, F., Zhao, Y., Cachau, R., Cousido-Siah, A., Ruiz, F.X., Harlos, K., Howard, E., Mitschler, A., Podjarny, A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBS:DI(N-ACETYL-D-GLUCOSAMINE)'>CBS</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-Description: Crystal structure of human chitotriosidase-1 catalytic domain in complex with chitobiose (2.5mM) at 1.10 A resolution
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wkf RCSB], [http://www.ebi.ac.uk/pdbsum/4wkf PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CHIT1_HUMAN CHIT1_HUMAN]] Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.<ref>PMID:7592832</ref> <ref>PMID:7836450</ref> <ref>PMID:9748235</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chitinase]]
+[[Category: Cachau, R]]
+[[Category: Cousido-Siah, A]]
 [[Category: Fadel, F]]
+[[Category: Harlos, K]]
+[[Category: Howard, E]]
+[[Category: Mitschler, A]]
 [[Category: Podjarny, A]]
-[[Category: Cachau, R]]
+[[Category: Ruiz, F X]]
-[[Category: Mitschler, A]]
-[[Category: Harlos, K]]
 [[Category: Zhao, Y]]
-[[Category: Cousido-Siah, A]]
+[[Category: Catalytic mechanism]]
-[[Category: Howard, E]]
+[[Category: Chit1]]
-[[Category: Ruiz, F.X]]
+[[Category: Gh18 chitinase]]
+[[Category: Hydrolase]]
+[[Category: Hydrolysis]]
+[[Category: Protonation state]]