4xa4: Difference between revisions

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'''Unreleased structure'''
==Crystal Structure of the coiled-coil surrounding Skip 3 of MYH7==
 
<StructureSection load='4xa4' size='340' side='right' caption='[[4xa4]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
The entry 4xa4 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4xa4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XA4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XA4 FirstGlance]. <br>
Authors: Taylor, K.C., Buvoli, M., Korkmaz, E.N., Buvoli, A., Zheng, Y., Heinz, N.T., Qiang, C., Leinwand, L.A., Rayment, I.
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xa1|4xa1]], [[4xa3|4xa3]], [[4xa6|4xa6]]</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xa4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xa4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xa4 RCSB], [http://www.ebi.ac.uk/pdbsum/4xa4 PDBsum]</span></td></tr>
Description:  
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Zheng, Y]]
[[http://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN]] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> 
[[Category: Leinwand, L.A]]
== References ==
[[Category: Heinz, N.T]]
<references/>
__TOC__
</StructureSection>
[[Category: Buvoli, A]]
[[Category: Buvoli, A]]
[[Category: Taylor, K.C]]
[[Category: Buvoli, M]]
[[Category: Buvoli, M]]
[[Category: Korkmaz, E.N]]
[[Category: Heinz, N T]]
[[Category: Korkmaz, E N]]
[[Category: Leinwand, L A]]
[[Category: Qiang, C]]
[[Category: Rayment, I]]
[[Category: Rayment, I]]
[[Category: Qiang, C]]
[[Category: Taylor, K C]]
[[Category: Zheng, Y]]
[[Category: Cardiac]]
[[Category: Coiled coil]]
[[Category: Eb1]]
[[Category: Fusion]]
[[Category: Gp7]]
[[Category: Motor protein]]
[[Category: Myh7]]
[[Category: Myosin]]
[[Category: Skip residue]]

Revision as of 15:22, 1 July 2015

Crystal Structure of the coiled-coil surrounding Skip 3 of MYH7Crystal Structure of the coiled-coil surrounding Skip 3 of MYH7

Structural highlights

4xa4 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[XRCC4_HUMAN] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.[1] [2] [3] [4]

References

  1. ↑ Li Z, Otevrel T, Gao Y, Cheng HL, Seed B, Stamato TD, Taccioli GE, Alt FW. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell. 1995 Dec 29;83(7):1079-89. PMID:8548796
  2. ↑ Chen L, Trujillo K, Sung P, Tomkinson AE. Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase. J Biol Chem. 2000 Aug 25;275(34):26196-205. PMID:10854421 doi:10.1074/jbc.M000491200
  3. ↑ Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA. Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol Cell Biol. 2000 May;20(9):2996-3003. PMID:10757784
  4. ↑ Foster RE, Nnakwe C, Woo L, Frank KM. Monoubiquitination of the nonhomologous end joining protein XRCC4. Biochem Biophys Res Commun. 2006 Mar 3;341(1):175-83. Epub 2006 Jan 6. PMID:16412978 doi:S0006-291X(05)02903-7

4xa4, resolution 2.33Å

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