4tl6: Difference between revisions

Revision as of 15:20, 1 July 2015

Crystal structure of N-terminal domain of KaiCCrystal structure of N-terminal domain of KaiC

Structural highlights

4tl6 is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	4tl7, 4tl8, 4tl9, 4tla, 4tlb, 4tlc, 4tld, 4tle
Activity:	Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.^[1] ^[2]

References

↑ Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T. Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science. 1998 Sep 4;281(5382):1519-23. PMID:9727980
↑ Nakahira Y, Katayama M, Miyashita H, Kutsuna S, Iwasaki H, Oyama T, Kondo T. Global gene repression by KaiC as a master process of prokaryotic circadian system. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):881-5. Epub 2004 Jan 6. PMID:14709675 doi:10.1073/pnas.0307411100

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OCA

[1] Ishiura M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T. Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria. Science. 1998 Sep 4;281(5382):1519-23. PMID:9727980

[2] Nakahira Y, Katayama M, Miyashita H, Kutsuna S, Iwasaki H, Oyama T, Kondo T. Global gene repression by KaiC as a master process of prokaryotic circadian system. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):881-5. Epub 2004 Jan 6. PMID:14709675 doi:10.1073/pnas.0307411100

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of N-terminal domain of KaiC==
+<StructureSection load='4tl6' size='340' side='right' caption='[[4tl6]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
-The entry 4tl6 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4tl6]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TL6 FirstGlance]. <br>
-Authors: Abe, J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tl7|4tl7]], [[4tl8|4tl8]], [[4tl9|4tl9]], [[4tla|4tla]], [[4tlb|4tlb]], [[4tlc|4tlc]], [[4tld|4tld]], [[4tle|4tle]]</td></tr>
-Description:
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tl6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4tl6 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Non-specific serine/threonine protein kinase]]
 [[Category: Abe, J]]
+[[Category: Akiyama, S]]
+[[Category: Hiyama, T B]]
+[[Category: Mukaiyama, A]]
+[[Category: Son, S]]
+[[Category: Serine/threonine-protein kinase]]
+[[Category: Transferase]]

4tl6: Difference between revisions

Revision as of 15:20, 1 July 2015

Crystal structure of N-terminal domain of KaiCCrystal structure of N-terminal domain of KaiC

Structural highlights

Function

References

Contents

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4tl6: Difference between revisions

Revision as of 15:20, 1 July 2015

Crystal structure of N-terminal domain of KaiCCrystal structure of N-terminal domain of KaiC

Structural highlights

Function

References

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