4wbg: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of class C beta-lactamase Mox-1 covalently complexed with aztorenam==
+<StructureSection load='4wbg' size='340' side='right' caption='[[4wbg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4wbg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WBG FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AZR:2-({[(1Z)-1-(2-AMINO-1,3-THIAZOL-4-YL)-2-OXO-2-{[(2S,3S)-1-OXO-3-(SULFOAMINO)BUTAN-2-YL]AMINO}ETHYLIDENE]AMINO}OXY)-2-METHYLPROPANOIC+ACID'>AZR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w8k|3w8k]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wbg RCSB], [http://www.ebi.ac.uk/pdbsum/4wbg PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We solved the crystal structure of a class C beta-lactamase MOX-1 complexed with an inhibitor, aztreonam, at 1.9A resolution. The main-chain oxygen of Ser315 interacts with the amide nitrogen of aztreonam. Surprisingly, compared to the free MOX-1 structure, this main-chain carboxyl changes its position significantly upon binding aztreonam. This result indicates that the interaction between MOX-1 and beta-lactams can be accompanied by conformational changes of the B3 beta-strand main chain.
-The entry 4wbg is ON HOLD  until Paper Publication
+A Conformational Change Observed in the Active Site of Class C beta-Lactamase MOX-1 in Binding Aztreonam.,Oguri T, Ishii Y, Shimizu-Ibuka A Antimicrob Agents Chemother. 2015 Jun 8. pii: AAC.04428-14. PMID:26055361<ref>PMID:26055361</ref>
-Authors: Oguri, T., Shimizu-ibuka, A., Ishii, Y.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Crystal structure of class C beta-lactamase Mox-1 covalently complexed with aztorenam
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Beta-lactamase]]
+[[Category: Ishii, Y]]
 [[Category: Oguri, T]]
-[[Category: Ishii, Y]]
+[[Category: Shimizu-ibuka, A]]
-[[Category: Shimizu-Ibuka, A]]
+[[Category: Acyl-intermediate]]
+[[Category: Aztreonam]]
+[[Category: Hydrolase]]