4ynh: Difference between revisions

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-'''Unreleased structure'''
+==Structure of the C. elegans SAS-5 Implico dimerization domain==
+<StructureSection load='4ynh' size='340' side='right' caption='[[4ynh]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ynh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YNH FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ynh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ynh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ynh RCSB], [http://www.ebi.ac.uk/pdbsum/4ynh PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SAS5_CAEEL SAS5_CAEEL]] Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.<ref>PMID:15232593</ref> <ref>PMID:15572125</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In C. elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional homologs across eukaryotic evolution. Whereas the molecular architecture of SAS-6 and its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and its relatives function is unclear. Here, we combine biophysical and structural analysis to uncover the architecture of SAS-5 and examine its functional implications in vivo. Our work reveals that two distinct self-associating domains are necessary to form higher-order oligomers of SAS-5: a trimeric coiled coil and a novel globular dimeric Implico domain. Disruption of either domain leads to centriole duplication failure in worm embryos, indicating that large SAS-5 assemblies are necessary for function in vivo.
-The entry 4ynh is ON HOLD  until Paper Publication
+The protein SAS-5 forms large oligomeric assemblies critical for centriole formation.,Rogala KB, Dynes NJ, Hatzopoulos GN, Yan J, Pong SK, Robinson CV, Deane CM, Gonczy P, Vakonakis I Elife. 2015 May 29;4. doi: 10.7554/eLife.07410. PMID:26023830<ref>PMID:26023830</ref>
-Authors: Rogala, K.B., Vakonakis, I., Hatzopoulos, G.N.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Structure of a C. elegans protein
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hatzopoulos, G N]]
+[[Category: Rogala, K B]]
 [[Category: Vakonakis, I]]
-[[Category: Hatzopoulos, G.N]]
+[[Category: Centriole]]
-[[Category: Rogala, K.B]]
+[[Category: Dimerization domain]]
+[[Category: Sas-5]]
+[[Category: Structural protein]]