Beta2 adrenergic receptor-Gs protein complex: Difference between revisions

Dan Elran (talk | contribs)
No edit summary
Dan Elran (talk | contribs)
No edit summary
Line 11: Line 11:


== G-Protein-GPCR Intercations ==
== G-Protein-GPCR Intercations ==
The a5-helix of Gas docks into a cavity formed on the intracellular side of the receptor by the opening of transmembrane helices 5 and 6. Within the transmembrane core, the interactions are primarily non-polar. An exception involves <scene name='70/701430/Receptor_g_protein_interaction/3'>packing of Tyr 391 of the a5-helix against Arg 131 of the conservedDRYsequence inTM3. Arg 131 also packs against Tyr 326 of the conserved
The a5-helix of Gas docks into a cavity formed on the intracellular side of the receptor by the opening of transmembrane helices 5 and 6. Within the transmembrane core, the interactions are primarily non-polar. An exception involves <scene name='70/701430/Receptor_g_protein_interaction/4'>packing of Tyr 391 of the a5-helix against Arg 131 of the conservedDRYsequence inTM3. Arg 131 also packs against Tyr 326 of the conserved
NPxxY sequence in TM7</scene>
NPxxY sequence in TM7</scene>


Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Dan Elran, Michal Harel, Joel L. Sussman, Alexander Berchansky