Neuroligin: Difference between revisions

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[[Image:3be8a.png|left|200px|thumb|Crystal Structure of human Neuroligin [[3be8]]]]
[[Image:3be8a.png|left|200px|thumb|Crystal Structure of human Neuroligin [[3be8]]]]
{{STRUCTURE_3b3q|  PDB=3b3q  | SIZE=400| SCENE= |right|CAPTION=Mouse neuroligin 1 LNS domain dimer (grey and green) complex with neurexin cholinesterase-like domain (pink and cyan) and Ca+2 ions (green) [[3b3q]] }}
{{STRUCTURE_3b3q|  PDB=3b3q  | SIZE=400| SCENE= |right|CAPTION=Dimer of two mouse neuroligin-1 cholinesterase-like domains (grey and green) in complex with two neurexin-beta1 LNS6 domain (pink and cyan) and Ca+2 ions (green) [[3b3q]] }}




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[[Neuroligin|Neuroligins]] (NLGN) are a family of postsynaptic proteins which bind to the presynaptic [[Neurexin]] (NRXN) to form a complex which attaches neurons.  The NLGN family contains 4 members which are numbered 1 to 4. See [[Neurodevelopmental Disorders]].
[[Neuroligin|Neuroligins]] (NLGN) are a family of postsynaptic proteins which bind to the presynaptic [[Neurexins]] (NRXN) to form a complex which attaches neurons.  In humans the NLGN family contains 4 to 5 members that are numbered 1, 2, 3, 4X and 5 or 4Y. See [[Neurodevelopmental Disorders]].


For Structural Analysis of Neuroligin, See: [[Neuroligin-Neurexin Interaction]]
For Structural Analysis of Neuroligin, See: [[Neuroligin-Neurexin Interaction]]

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Alexander Berchansky, Jaime Prilusky, David Canner, Michal Harel, Pascale Marchot, Joel L. Sussman