4yfl: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120==
+<StructureSection load='4yfl' size='340' side='right' caption='[[4yfl]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
-The entry 4yfl is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yfl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YFL FirstGlance]. <br>
-Authors: Acharya, P., Zhou, T., Moquin, S., Kwong, P.D.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yfl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yfl RCSB], [http://www.ebi.ac.uk/pdbsum/4yfl PDBsum]</span></td></tr>
-Description: Crystal structure of VH1-46 germline derived HIV-1 neutralizing antibody 1B2530 in complex with 93TH057 gp120
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447]  The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
+__TOC__
+</StructureSection>
 [[Category: Acharya, P]]
-[[Category: Kwong, P.D]]
+[[Category: Kwong, P D]]
 [[Category: Moquin, S]]
 [[Category: Zhou, T]]
+[[Category: Broadly neutralizing antibody]]
+[[Category: Hiv-1 cd4 binding site]]
+[[Category: Immune system]]