4y2e: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S)==
 
<StructureSection load='4y2e' size='340' side='right' caption='[[4y2e]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
The entry 4y2e is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4y2e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y2E FirstGlance]. <br>
Authors: Lountos, G.T., Austin, B.P., Tropea, J.E., Waugh, D.S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y2e RCSB], [http://www.ebi.ac.uk/pdbsum/4y2e PDBsum]</span></td></tr>
Description: Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S)
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Austin, B.P]]
[[http://www.uniprot.org/uniprot/DUS7_HUMAN DUS7_HUMAN]] Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.<ref>PMID:14603440</ref> 
[[Category: Tropea, J.E]]
== References ==
[[Category: Waugh, D.S]]
<references/>
[[Category: Lountos, G.T]]
__TOC__
</StructureSection>
[[Category: Austin, B P]]
[[Category: Lountos, G T]]
[[Category: Tropea, J E]]
[[Category: Waugh, D S]]
[[Category: Dual specificity phosphatase]]

Revision as of 15:46, 3 June 2015

Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S)Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S)

Structural highlights

4y2e is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[DUS7_HUMAN] Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.[1]

References

  1. ↑ Levy-Nissenbaum O, Sagi-Assif O, Witz IP. Characterization of the dual-specificity phosphatase PYST2 and its transcripts. Genes Chromosomes Cancer. 2004 Jan;39(1):37-47. PMID:14603440 doi:http://dx.doi.org/10.1002/gcc.10295

4y2e, resolution 1.67Å

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OCA
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