Reverse transcriptase: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, Daniel Moyano-Marino, Lynmarie K Thompson, Alexander Berchansky, David Canner, Jaime Prilusky, Brian Foley, Michal Harel, Amol Kapoor, Joel L. Sussman

@@ Line 78: / Line 78: @@
 **[[1s1t]], [[1s1v]], [[1s1w]], [[1s6p]], [[1s6q]], [[1s9e]], [[1s9g]], [[1suq]], [[1sv5]], [[3dm2]], [[3dmj]], [[3dok]], [[3dol]], [[2opq]], [[2opr]], [[2ops]], [[2ic3]], [[2hnz]], [[1jlg]], [[1bqn]], [[1uwb]], [[1tvr]], [[3qo9]], [[3t1a]]  - P66/P51 (mutant)+NNRTI<br />
 **[[3kk1]], [[1c1b]], [[1rti]], [[4kv8]] - P66/P51+ inhibitor<br />
-**[[2ynf]], [[2yng]], [[2ynf]], [[2yng]] - P66/P51 (mutant) + NNRTI <br />
+**[[2ynf]], [[2yng]], [[2ynf]], [[2yng]], [[4kko]], [[4lsl]], [[4lsn]], [[4mfb]], [[4o44]], [[4o4g]] - P66/P51 (mutant) + NNRTI <br />
 **[[1jla]] - P66/P51 (mutant)+ NRTI<br />
 **[[3ig1]] - P66/P51+ inhibitor beta-thujaplicinol<br />
 **[[3i0r]], [[3i0s]], [[3m8q]], [[3isn]], [[3ith]], [[1c1c]], [[3nbp]]  - P66/P51+ pyrimidine derivative<br />
-**[[1ikx]] - P66/P51 (mutant)+ pyrimidine derivative<br />
+**[[1ikx]], [[4ko0]] - P66/P51 (mutant)+ pyrimidine derivative<br />
 **[[1tv6]] - P66/P51+ pyridine derivative<br />
 **[[1jlc]], [[1iky]], [[1eet]] - P66/P51(mutant)+ pyridine derivative<br />
@@ Line 92: / Line 92: @@
 **[[1rt4]], [[1rt5]], [[1rt6]], [[1rt7]] - P66/P51+ carboxanilide derivative<br />
 **[[1klm]] - P66/P51+piperazine derivative<br />
-**[[2jle]] – P66+NNRTI<br />
+* HIV-1 reverse transcriptase complex with DNA/RNA
 **[[3kjv]], [[3kk3]], [[1r0a]], [[1n5y]], [[1n6q]], [[1hys]] - P66/P51+DNA<br />
 **[[1j5o]], [[1rtd]], [[3klf]], [[3v4i]], [[3v6d]] - P66/P51 (mutant)+DNA<br />
+**[[4r5p]] - P66/P51 (mutant) + dATP mimic + DNA<br />
 **[[3v81]] - P66/P51 (mutant)+DNA + NNRTI<br />
 **[[1hvu]] - P66/P51+RNA<br />
 **[[4b3o]], [[4b3p]], [[4b3q]] - P66/P51 + RNA + DNA<br />
+**[[4pqu]] - P66/P51 (mutant) + dATP + RNA + DNA<br />
+**[[4puo]], [[4pwd]], [[4q0b]] - P66/P51 (mutant) + nevirapine + RNA + DNA<br />
 **[[1t03]], [[1t05]] - P66/P51+DNA+Fab+NRTI<br />
 **[[3jsm]] - P66/P51 (mutant)+DNA+NRTI<br />
@@ Line 115: / Line 120: @@
 **[[1har]] - P66 N-terminal
-*HIV-1 reverse transcriptase P15
+*RT/ribonuclease H domain or Hiv-1 P15
+**[[4mh8]] – MmlvRT P80<br />
+**[[4m94]], [[4m95]] – MmlvRT P80 catalytic fragment + DNA<br />
+**[[4ifv]] – Hiv1P66/P55 (mutant) <br />
+**[[2ykm]], [[2ykn]] – Hiv1P66 (mutant) + NNRTI <br />
+**[[4qag]] – Hiv1P66 + coumarin derivative <br />
+**[[4h4m]] – Hiv1P66/P55 (mutant) + NNRTI <br />
+**[[4h4o]], [[4rw4]], [[4rw6]], [[4rw7]], [[4rw8]], [[4rw9]] – Hiv1P66/P51 (mutant) + NNRTI <br />
+**[[2ynh]], [[2yni]], [[4ncg]] – Hiv1P66/P51 + NNRTI <br />
 **[[1rdh]], [[1hrh]] – P15<br />
 **[[3lp3]] – P15+inhibitor MK3<br />
@@ Line 127: / Line 140: @@
 **[[1mu2]] - RT (mutant)
-* Leukemia virus reverse transcriptase
+* Moloney murine leukemia virus reverse transcriptase
-**[[2hb5]], [[1mml]] - catalytic fragment<br />
+**[[2hb5]], [[1mml]] - MmlvRT catalytic fragment<br />
-**[[2r2r]], [[2r2t]], [[2fjv]], [[2fjw]], [[2fjx]], [[1ztw]], [[2fvs]], [[2fvr]], [[2fvq]], [[2fvp]], [[1n4l]] – catalytic fragment+DNA<br />
+**[[2r2r]], [[2r2t]], [[2fjv]], [[2fjw]], [[2fjx]], [[1ztw]], [[2fvs]], [[2fvr]], [[2fvq]], [[2fvp]], [[1n4l]], [[4xo0]], [[4xpc]], [[4xpe]] – MmlvRT catalytic fragment+DNA<br />
-**[[2r2s]], [[2r2u]] - catalytic fragment+DNA+Co Bleomycin<br />
+**[[2r2s]], [[2r2u]] - MmlvRT catalytic fragment+DNA+Co Bleomycin<br />
-**[[1ztt]] - catalytic fragment+DNA+netropsin<br />
+**[[1ztt]] - MmlvRT catalytic fragment+DNA+netropsin<br />
-**[[1rw3]], [[1nnd]] – fragment (mutant)<br />
+**[[1rw3]], [[1nnd]] – MmlvRT fragment (mutant)<br />
-**[[1i6j]], [[1d0e]], [[1d1u]], [[1qaj]], [[1qai]] – N-terminal+DNA<br />
+**[[1i6j]], [[1d0e]], [[1d1u]], [[1qaj]], [[1qai]] – MmlvRT N-terminal+DNA<br />
-**[[3fsi]] - catalytic fragment+DNA+trypanocidal
+**[[3fsi]] - MmlvRT catalytic fragment+DNA+trypanocidal
 *XMRV reverse transcriptase
@@ Line 147: / Line 160: @@
 *Reverse transcriptase from telomerase
-**[[2b2a]] - RT telomerase catalytic subunit (mutant) - ''Tetrahymena thermophila''<br />
+**[[2b2a]] - TtRT telomerase catalytic subunit (mutant) - ''Tetrahymena thermophila''<br />
-**[[2r4g]] - RT telomerase RNA-binding domain<br />
+**[[2r4g]] - TtRT telomerase RNA-binding domain<br />
 **[[3du6]], [[3du5]] - TcRT telomerase catalytic subunit - ''Tribolium castaneum''<br />
-**[[3kyl]] - TcRT telomerase catalytic subunit + DNA
+**[[3kyl]] - TcRT telomerase catalytic subunit + DNA<br />
+**[[4o26]] – RT RNA-binding domain + RNA – rice fish<br />
+**[[4lmo]] - RT telomerase RNA-binding domain – tiger puffer<br />
 }}
 ==See Also==