SCF-KIT: Difference between revisions
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'''Stem cell factor (SCF)''' is a cytokine that mediates its diverse cellular responses by binding to and activating the receptor tyrosine kinase (RTK) KIT (also known as SCF receptor). SCF functions as a noncovalent homodimer, and both membrane-anchored and soluble forms of SCF have been described. | '''Stem cell factor (SCF)''' is a cytokine that mediates its diverse cellular responses by binding to and activating the [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase (RTK)] KIT (also known as SCF receptor). SCF functions as a noncovalent homodimer, and both membrane-anchored and soluble forms of SCF have been described. | ||
KIT was initially discovered as an oncogene in a feline retrovirus. | KIT was initially discovered as an oncogene in a feline retrovirus. | ||
SCF and KIT are required for a normal development of hematopoietic cells, melanocytes and others. In humans, loss-of-function mutations in KIT cause thepiebald trait. A variety of gain-of-function mutations in KIT were found in different types of human cancers such as gastro-intestinal-stromal tumors, acute myeloid leukemia, and mast cell leukemia. | SCF and KIT are required for a normal development of hematopoietic cells, melanocytes and others. In humans, loss-of-function mutations in KIT cause thepiebald trait. A variety of gain-of-function mutations in KIT were found in different types of human cancers such as gastro-intestinal-stromal tumors, acute myeloid leukemia, and mast cell leukemia. | ||