4yub: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human Nicotinic Acid Phosphoribosyltransferase==
 
<StructureSection load='4yub' size='340' side='right' caption='[[4yub]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
The entry 4yub is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4yub]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YUB FirstGlance]. <br>
Authors: Garavaglia, S., Rizzi, M., Marletta, A.S.
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate_phosphoribosyltransferase Nicotinate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.21 6.3.4.21] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yub RCSB], [http://www.ebi.ac.uk/pdbsum/4yub PDBsum]</span></td></tr>
Description: Crystal structure of human Nicotinic Acid Phosphoribosyltransferase
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Marletta, A.S]]
[[http://www.uniprot.org/uniprot/PNCB_HUMAN PNCB_HUMAN]] Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.<ref>PMID:17604275</ref>  Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Nicotinate phosphoribosyltransferase]]
[[Category: Garavaglia, S]]
[[Category: Garavaglia, S]]
[[Category: Marletta, A S]]
[[Category: Rizzi, M]]
[[Category: Rizzi, M]]
[[Category: Fk866 recycling]]
[[Category: Ligase]]
[[Category: Nad biosynthesis]]
[[Category: Nad pathway]]
[[Category: Nicotinic acid preiss handler pathway]]
[[Category: Phosphoribosyl transferase]]

Revision as of 15:20, 20 May 2015

Crystal structure of human Nicotinic Acid PhosphoribosyltransferaseCrystal structure of human Nicotinic Acid Phosphoribosyltransferase

Structural highlights

4yub is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Nicotinate phosphoribosyltransferase, with EC number 6.3.4.21
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[PNCB_HUMAN] Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.[1] Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

References

  1. ↑ Hara N, Yamada K, Shibata T, Osago H, Hashimoto T, Tsuchiya M. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. J Biol Chem. 2007 Aug 24;282(34):24574-82. Epub 2007 Jun 29. PMID:17604275 doi:http://dx.doi.org/10.1074/jbc.M610357200

4yub, resolution 2.90Å

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