2zb0: Difference between revisions

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Revision as of 19:53, 20 March 2008

File:2zb0.jpg

, resolution 2.100Å

Ligands:

and

Activity:

Mitogen-activated protein kinase, with EC number 2.7.11.24

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of P38 in complex with biphenyl amide inhibitor

OverviewOverview

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

About this StructureAbout this Structure

2ZB0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306

Page seeded by OCA on Thu Mar 20 18:53:27 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2zb0.jpg|left|200px]]<br /><applet load="2zb0" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2zb0.jpg|left|200px]]
-caption="2zb0, resolution 2.100&Aring;" />
-'''Crystal structure of P38 in complex with biphenyl amide inhibitor'''<br />
+ {{Structure
+|PDB= 2zb0 |SIZE=350|CAPTION= <scene name='initialview01'>2zb0</scene>, resolution 2.100&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=GK3:'>GK3</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24]
+|GENE=
+}}
+'''Crystal structure of P38 in complex with biphenyl amide inhibitor'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-ZB0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GK3:'>GK3</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZB0 OCA].
+ZB0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZB0 OCA].
 ==Reference==
-Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18006306 18006306]
+Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18006306 18006306]
 [[Category: Homo sapiens]]
 [[Category: Mitogen-activated protein kinase]]
@@ Line 28: / Line 37: @@
 [[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:01:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:53:27 2008''