Adenylosuccinate Synthetase: Difference between revisions
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<StructureSection load='3hid' size='400' side='right' scene='' caption='Monomer of the dimeric adenylosuccinate synthase complex with ligand PG6, [[3hid]]'> | |||
==Introduction== | ==Introduction== | ||
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Defects in the gene product can result in a wide variety of diseases such as Acidosis, Gout, Neoplasms, Sarcoma, Leukemia and Lymphoma<ref>PMID:7438071</ref>. Since AdSS plays a crucial role in purine catalysis, it is a choice target for anti tumor drugs and antibiotics. A variety of enzymes are found to be improperly balanced in cancer cells, including AdSS which is found to be over expressed 5.5 times as much as it would normally be.<ref>PMID: 6861338</ref> | Defects in the gene product can result in a wide variety of diseases such as Acidosis, Gout, Neoplasms, Sarcoma, Leukemia and Lymphoma<ref>PMID:7438071</ref>. Since AdSS plays a crucial role in purine catalysis, it is a choice target for anti tumor drugs and antibiotics. A variety of enzymes are found to be improperly balanced in cancer cells, including AdSS which is found to be over expressed 5.5 times as much as it would normally be.<ref>PMID: 6861338</ref> | ||
</StructureSection> | |||
==3D structures of Adenylosuccinate Synthetase== | ==3D structures of Adenylosuccinate Synthetase== | ||