Sandbox PgpWWC: Difference between revisions

For the BBB, this protein prevents the entry of many psychotherapeutic drugs. For chemotherapeutic treatments, the inter individual variance can prevent the accumulation of the drugs, who interactions could increase the toxicity. ABCB1 is an important component of understanding the adverse drug reactions for individuals.<ref name="Marchetti" /> The interactions of multiple therapeutic drugs and herbal medicines in ABCB1 can stimulate or prevent the accumulation of compounds in cells. In order to explore the implications of interactions, further research is needed to determine the binding sites and interactions of various compounds to identify possible harmful interactions in therapeutic treatments. <ref name="Zhou">PMID: 15072439</ref> Thus, administering pharmacotherapeutics with ABCB1 blockers could increase the accumulation of the drugs by preventing the efflux, but further research is needed to determine the interactions and the safe administration dosage.<ref name="Schinkel">PMID: 10837715</ref>

== References ==

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