|
|
Line 43: |
Line 43: |
|
| |
|
| **[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> | | **[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> |
| **[[4nb4]] - SaPanK + ADP + pantothenamide<br /> | | **[[4nb4]], [[4m7x]], [[4m7y]] - SaPanK + ADP + pantothenate derivative<br /> |
|
| |
|
| *'''PanK III''' | | *'''PanK III''' |
Revision as of 13:33, 7 May 2015
Template:STRUCTURE 2f9w
Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.
3D structures of pantothenate kinase3D structures of pantothenate kinase
Updated on 07-May-2015
{"openlevels":0}
- PanK I
- 1esm – EcPanK + CoA – Escherichia coli
- 1esn - EcPanK + ANP
- 1sq5 - EcPanK + ADP + PAU
- 3tqc - PanK – Coxiella burnetii
- PanK I binary complex
- 2ges, 2get, 2zs7, 2geu, 2gev - MtPanK + CoA derivative – Mycobacterium tuberculosis
- 2zs8, 2zsb - MtPanK + ADP
- 3af1 - MtPanK + GDP
- 3af2 - MtPanK + AMPPCP
- 3af4 - MtPanK + GMPPCP
- 2zsd - MtPanK + CoA
- 3avo - MtPanK + PAU
- 3avp, 3avq - MtPanK + PAU derivative
- 4bfs, 4bft, 4bfu, 4bfv, 4bfw, 4bfx - MtPanK + triazole inhibitor
- 4bfy, 4bfz - MtPanK + biaryl inhibitor
- PanK I ternary complex
- 2zs9 - MtPanK + ADP + PAU
- 2zse - MtPanK + AMPPCP + PAU
- 3af3 - MtPanK + GMPPCP + PAU
- 2zsf - MtPanK + ADP + ATP
- 2zsa - MtPanK + ADP + PPT
- 3aez - MtPanK + GDP + PPT
- 3af0 - MtPanK + GDP + PAU
- 4f7w, 4ne2 – KpPanK + ADP + pantothenamide derivative – Klebsiella pneumonia
- 4gi7 – KpPanK + ADP + pantothenate analog
- PanK II
- 2ews - SaPanK + ANP – Staphylococcus aureus
- 4nb4, 4m7x, 4m7y - SaPanK + ADP + pantothenate derivative
- PanK III
- 2gtd - TmPanK – Thermotoga maritima
- 2f9t – PaPanK – Pseudomonas aeruginosa
- 2h3g - PanK – Bacillus anthracis
- 3djc - PanK – Legionella pneumophila
- 4o8k - BtPanK – Burkholderia thailandensis
- PanK III binary complex
- PanK III ternary complex
- 3bf1 - TmPanK + ADP + PAU
- 4o5f - BtPanK + ADP + PAU
- Human PanK
proteopedia link