Interleukin: Difference between revisions
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* '''IL-8''' induces chemotaxis and phagocytosis.<br /> | * '''IL-8''' induces chemotaxis and phagocytosis.<br /> | ||
* '''IL-10''' see [[Interleukin-10]].<br /> | * '''IL-10''' see [[Interleukin-10]].<br /> | ||
*''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br /> | * '''IL-11''' involved in the stimulation of megakaryocyte maturation.<br /> | ||
* ''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br /> | |||
* '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | * '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | ||
* '''IL-15''' see [[Interleukin-15]].<br /> | * '''IL-15''' see [[Interleukin-15]].<br /> | ||
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* '''IL-18''' induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br /> | * '''IL-18''' induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br /> | ||
* '''IL-19''' induces activation of the signal transducer and activator of STAT3.<br /> | * '''IL-19''' induces activation of the signal transducer and activator of STAT3.<br /> | ||
*''' IL-21''' has potent effect on natural killer cells.<br /> | * ''' IL-21''' has potent effect on natural killer cells.<br /> | ||
* '''IL-22''' stimulates inflammatory responses like S100 and defensin.<br /> | * '''IL-22''' stimulates inflammatory responses like S100 and defensin.<br /> | ||
*''' IL-23''' induces activation of the signal transducer and activator of STAT4.<br /> | * ''' IL-23''' induces activation of the signal transducer and activator of STAT4.<br /> | ||
* '''IL-28''' has a role in the immune defense against viruses.<br /> | * '''IL-28''' has a role in the immune defense against viruses.<br /> | ||
* '''IL-29''' similar to IL-28.<br /> | * '''IL-29''' similar to IL-28.<br /> | ||
* '''IL-33''' induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br /> | * '''IL-33''' induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br /> | ||
* '''IL-34''' increases growth or survival of monocytes.<br /> | * '''IL-34''' increases growth or survival of monocytes.<br /> | ||
* '''IL-36''' acts on naïve CD4+ T cells. | |||
==3D structures of interleukin== | ==3D structures of interleukin== | ||
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**[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR /> | **[[1qvn]], [[1nbp]], [[1m4a]], [[1m4b]] – hIL-2 (mutant) + inhibitor<BR /> | ||
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR /> | **[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR /> | ||
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR /> | |||
*IL-3 | *IL-3 | ||
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**[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR /> | **[[3bpl]] - hIL-4 + IL-4 receptor α + cytokine receptor common γ<BR /> | ||
**[[3qb7]] - hIL-4 + cytokine receptor common γ<BR /> | **[[3qb7]] - hIL-4 + cytokine receptor common γ<BR /> | ||
**[[4ydy]] – hIL-4 + darpin<BR /> | |||
**[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α | **[[3bpn]] - hIL-4 + IL-4 receptor α + IL-13 receptor α | ||
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**[[4j4l]] – hIL-6 + internalin B<BR /> | **[[4j4l]] – hIL-6 + internalin B<BR /> | ||
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR /> | **[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR /> | ||
**[[4cni]], [[4o9h]] – hIL-6 + antibody<BR /> | |||
*IL-7 | *IL-7 | ||
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**[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR /> | **[[2h24]], [[1inr]], [[2ilk]], [[1ilk]] – hIL-10<BR /> | ||
**[[4x51]] – mIL-10<BR /> | |||
**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR /> | **[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR /> | ||
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α | **[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α | ||
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**[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR /> | **[[1lqs]] - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5<BR /> | ||
**[[1lk3]] - hvIL-10 residues 26-175 + antibody | **[[1lk3]] - hvIL-10 residues 26-175 + antibody | ||
*IL-11 | |||
**[[4mhl]] - hIL-11<br /> | |||
*IL-12 | *IL-12 | ||
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**[[1f42]] - hIL-12 β P40 domain<BR /> | **[[1f42]] - hIL-12 β P40 domain<BR /> | ||
**[[3hmx]] - hIL-12 α and β+ antibody<br /> | **[[3hmx]] - hIL-12 α and β+ antibody<br /> | ||
**[[4oe8]], [[4og9]] - hIL-12 β + hIL-23 α + alphabody MB3<br /> | |||
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin | **[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin | ||
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*IL-18 (Interferon-γ inducing factor) | *IL-18 (Interferon-γ inducing factor) | ||
**[[3wo2]] – hIL-18 <BR /> | |||
**[[1j0s]] – hIL-18 - NMR<BR /> | **[[1j0s]] – hIL-18 - NMR<BR /> | ||
**[[4hjj]] - hIL-18 + antibody<br /> | **[[4hjj]] - hIL-18 + antibody<br /> | ||
**[[2vxt]] - hIL-18 (mutant) + antibody<BR /> | **[[2vxt]] - hIL-18 (mutant) + antibody<BR /> | ||
**[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br /> | **[[3f62]] - hIL-18 residues 37-193 (mutant) + IL-18 binding protein<br /> | ||
**[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein | **[[4eee]], [[4ekx]] - hIL-18 (mutant) + 14L protein<br /> | ||
**[[3wo3]], [[4r6u]] - hIL-18 + IL-18 receptor<br /> | |||
**[[3wo4]] - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein<br /> | |||
*IL-19 | *IL-19 | ||
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**[[1ykb]], [[1m4r]] – hIL-22<BR /> | **[[1ykb]], [[1m4r]] – hIL-22<BR /> | ||
**[[4ok6]] – IL-22 – zebra fish<BR /> | |||
**[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR /> | **[[3g9v]] - hIL-22 residues 29-179 + IL-22 receptor α2<BR /> | ||
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br /> | **[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br /> | ||
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**[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br /> | **[[4exp]] - mIL-34 active core + macrophage colony-stimulating factor 1 receptor<br /> | ||
**[[4dke]], [[4dkf]] - hIL-34 active core + antibody | **[[4dke]], [[4dkf]] - hIL-34 active core + antibody | ||
*IL-36 | |||
**[[4ize]] - hIL-36 γ<br /> | |||
}} | }} | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||