Interleukin: Difference between revisions
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'''Interleukin''' (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.<br /> | '''Interleukin''' (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.<br /> | ||
* IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See [[Interleukin-1 beta]].<br /> | * '''IL-1''' is a group of 11 cytokines which regulate immune and inflammatory response. See [[Interleukin-1 beta]].<br /> | ||
* IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.<br /> | * '''IL-2''' is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.<br /> | ||
* IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.<br /> | * '''IL-3''' improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.<br /> | ||
* IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | * '''IL-4''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | ||
* IL-5 stimulates B cell growth and increases immunoglobulin secretion.<br /> | * '''IL-5''' stimulates B cell growth and increases immunoglobulin secretion.<br /> | ||
* IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.<br /> | * '''IL-6''' is both a pro-inflammatory cytokine and anti-inflammatory myokine.<br /> | ||
* IL-7 is a cytokine important for B and T cells development.<br /> | * '''IL-7''' is a cytokine important for B and T cells development.<br /> | ||
* IL-8 induces chemotaxis and phagocytosis.<br /> | * '''IL-8''' induces chemotaxis and phagocytosis.<br /> | ||
* IL-10 see [[Interleukin-10]].<br /> | * '''IL-10''' see [[Interleukin-10]].<br /> | ||
* IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br /> | *''' IL-12''' induces the differentiation of naive helper T cells (Th0) to Th1 cells.<br /> | ||
* IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | * '''IL-13''' induces the differentiation of naive helper T cells (Th0) to Th2 cells.<br /> | ||
* IL-15 see [[Interleukin-15]].<br /> | * '''IL-15''' see [[Interleukin-15]].<br /> | ||
* IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.<br /> | * '''IL-16''' acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.<br /> | ||
* IL-17 recruits monocytes and neutrophils to the site of inflammation.<br /> | * '''IL-17''' recruits monocytes and neutrophils to the site of inflammation.<br /> | ||
* IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br /> | * '''IL-18''' induces cell-mediated immunity following infection by microbial lipopolysaccharides.<br /> | ||
* IL-19 induces activation of the signal transducer and activator of STAT3.<br /> | * '''IL-19''' induces activation of the signal transducer and activator of STAT3.<br /> | ||
* IL-21 has potent effect on natural killer cells.<br /> | *''' IL-21''' has potent effect on natural killer cells.<br /> | ||
* IL-22 stimulates inflammatory responses like S100 and defensin.<br /> | * '''IL-22''' stimulates inflammatory responses like S100 and defensin.<br /> | ||
* IL-23 induces activation of the signal transducer and activator of STAT4.<br /> | *''' IL-23''' induces activation of the signal transducer and activator of STAT4.<br /> | ||
* IL-28 has a role in the immune defense against viruses.<br /> | * '''IL-28''' has a role in the immune defense against viruses.<br /> | ||
* IL-29 similar to IL-28.<br /> | * '''IL-29''' similar to IL-28.<br /> | ||
* IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br /> | * '''IL-33''' induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.<br /> | ||
* IL-34 increases growth or survival of monocytes.<br /> | * '''IL-34''' increases growth or survival of monocytes.<br /> | ||
==3D structures of interleukin== | ==3D structures of interleukin== | ||