Sandbox Reserved 1053: Difference between revisions
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== Background == | == Background == | ||
The antigen 85 (ag85) complex in ''Mycobacterium tuberculosis,'' which is responsible for causing the disease Tuberculosis, is composed of three intracellular membrane proteins: Ag85A, B, and C. The Ag85 complex is a major component of the cell wall, with each protein catalyzing the transfer of important cell wall constituents into the membrane. <ref>PMID: 10655617</ref> Ag85C is of particular interest due to its transfer of mycolic acids, which are major components in determining cell wall integrity. By targeting this mycoloyltransferase activity, inhibition of Ag85C offers potential for cell wall disruption and subsequent antibiotic targeting for normally drug-resistant ''Mycotaberia tuberculosis''. <ref>PMID: 10200974</ref> | The antigen 85 (ag85) complex in ''Mycobacterium tuberculosis,'' which is responsible for causing the disease Tuberculosis, is composed of three intracellular membrane proteins: Ag85A, B, and C. The Ag85 complex is a major component of the cell wall, with each protein catalyzing the transfer of important cell wall constituents into the membrane. <ref>PMID: 10655617</ref> The cell wall of ''Mycobacterium tuberculosis'' is composed of three primary molecules: peptidoglycans, arbinogalactans, and mycolic acids. Ag85C is of particular interest due to its transfer of mycolic acids, which are major components in determining cell wall integrity. By targeting this mycoloyltransferase activity, inhibition of Ag85C offers potential for cell wall disruption and subsequent antibiotic targeting for normally drug-resistant ''Mycotaberia tuberculosis''. <ref>PMID: 10200974</ref> | ||
==Structure== | ==Structure== | ||
<StructureSection load='1dqz' size='400' side='right' caption='Antigen 85C in ''Mycobacterium Tuberculosis''' scene=''> | <StructureSection load='1dqz' size='400' side='right' caption='Antigen 85C in ''Mycobacterium Tuberculosis''' scene=''> | ||