Hepatocyte growth factor: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='1shy' size='350' side='right' caption='Structure of human HGF β chain (grey) complex with HGF receptor Sema and ψ domains (green) (PDB entry [[1shy]])' scene=''> | <StructureSection load='1shy' size='350' side='right' caption='Structure of human HGF β chain (grey) complex with HGF receptor Sema and ψ domains (green) (PDB entry [[1shy]])' scene=''> | ||
'''Hepatocyte growth factor''' (HGF) regulates cell growth, motility and morphogenesis. HGF binds to proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade. HGF precursor is cleaved by serine protease to α and β ( | '''Hepatocyte growth factor''' (HGF) regulates cell growth, motility and morphogenesis. HGF binds to proto-oncogene c-Met receptor and activates a tyrosine kinase signaling cascade. HGF precursor is cleaved by serine protease to α (69 kD) and β (34 kD) chains which form a disulfide bond to produce the active heterodimer. '''HGF NK1''' variant is comprised of residues 28-210 containing the N-terminus and the first kringle domain of HGF. '''HGF NK2''' variant is comprised of residues 28-289 containing the N-terminus and the first 2 kringle domains of HGF. | ||
</StructureSection> | </StructureSection> | ||
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**[[3sp8]] – hHGF NK2 (mutant) + heparin<br /> | **[[3sp8]] – hHGF NK2 (mutant) + heparin<br /> | ||
**[[4iua]] – mHGF NK2 (mutant) <br /> | **[[4iua]] – mHGF NK2 (mutant) <br /> | ||
*HGF α chain (69 kD) | |||
**[[4o3t]], [[4o3u]] – hHGF α chain (mutant) + HGF receptor Sema and ψ domains + zymogen activator peptide<br /> | |||
*HGF β chain | *HGF β chain | ||