Sandbox Reserved 1070: Difference between revisions
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===Potential for Binding Amino Acids=== | ===Potential for Binding Amino Acids=== | ||
The exploration of this role for MgtC was first considered because of the ACT domain-like structure of the C-terminal domain. | The exploration of this role for MgtC was first considered because of the ACT domain-like structure of the C-terminal domain. | ||
ACT domains commonly bind small amino acids within the cell as a form of [http://geneontology.org/page/regulation regulation]. Yang ''et al''. showed that the structure of the C-terminal domain overlaps significantly with the structure of [http://proteopedia.org/wiki/index.php/1psd SerA] (PDB: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1psd 1PSD]), a known amino acid-binding ACT domain from ''[http://www.cdc.gov/ecoli/ E. coli]''. '''Figure 1A''' shows the overlap of these two proteins; the cyan protein represents MgtC and the orange protein represents SerA. However, the glycine that is critical for the binding of amino acids in these ACT domains has been substituted in MgtC with a <scene name='69/698113/Sub_residues_of_sera/ | ACT domains commonly bind small amino acids within the cell as a form of [http://geneontology.org/page/regulation regulation]. Yang ''et al''. showed that the structure of the C-terminal domain overlaps significantly with the structure of [http://proteopedia.org/wiki/index.php/1psd SerA] (PDB: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1psd 1PSD]), a known amino acid-binding ACT domain from ''[http://www.cdc.gov/ecoli/ E. coli]''. '''Figure 1A''' shows the overlap of these two proteins; the cyan protein represents MgtC and the orange protein represents SerA. However, the glycine that is critical for the binding of amino acids in these ACT domains has been substituted in MgtC with a <scene name='69/698113/Sub_residues_of_sera/2'>tyrosine</scene>, likely abolishing any potential amino acid binding activity <ref name="mgtc"/> | ||
===Potential for Chelation=== | ===Potential for Chelation=== | ||