Sandbox Reserved 1051: Difference between revisions
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=='''Mutations and Modifications'''== | =='''Mutations and Modifications'''== | ||
Researchers hold particular interest in specific geometric restraints caused by ligands introduced in various Ag85C mutants and modifications: Ag85C-ebselen, Ag85C-Hg, Ag85C-E228Q, and Ag85C- H260Q. The results demonstrate that modification of Ag85C by [http://en.wikipedia.org/wiki/Thiol thiol]-reactive compounds imparts structural changes in the enzyme’s active site. Specifically, scientists note a disruption in the natural kink in helix alpha-9. The resulting relaxed conformation of the helix significantly reduces or completely eliminates the enzymatic function of Ag85C. (Favrot) | Researchers hold particular interest in specific geometric restraints caused by ligands introduced in various Ag85C mutants and modifications: Ag85C-ebselen, Ag85C-Hg, <scene name='69/694218/Ag85c-e228q/1'>Ag85C-E228Q</scene>, and Ag85C- H260Q. The results demonstrate that modification of Ag85C by [http://en.wikipedia.org/wiki/Thiol thiol]-reactive compounds imparts structural changes in the enzyme’s active site. Specifically, scientists note a disruption in the natural kink in helix alpha-9. The resulting relaxed conformation of the helix significantly reduces or completely eliminates the enzymatic function of Ag85C. (Favrot) | ||
===Ag85C-ebselen=== | ===Ag85C-ebselen=== | ||