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A high conserved residue in the C-terminal region,<scene name='69/694233/Lys_487/2'>Lys 487</scene>, resulted in a 95% loss of function of FadD13 and is thought to be involved in the orientation of the substrates to form the adenylate intermediate.<ref name="residue paper">PMID: 20027301</ref> Other mutation studies, found that Serine 404 was involved in the binding of Coenzyme A which may only occur once the region incurs a 140 degree rotational change.<ref name="Our Paper"/><ref name="residue paper"/>
A high conserved residue in the C-terminal region, <scene name='69/694233/Lys_487/2'>Lysine 487</scene>, resulted in a 95% loss of function of FadD13 and is thought to be involved in the orientation of the substrates to form the adenylate intermediate.<ref name="residue paper">PMID: 20027301</ref> Other mutation studies, found that Serine 404 was involved in the binding of Coenzyme A which may only occur once the region incurs a 140 degree rotational change.<ref name="Our Paper"/><ref name="residue paper"/>




Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Joseph Thomas, Geoffrey C. Hoops, Isaac C. Gluesenkamp