4x1b: Difference between revisions

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-'''Unreleased structure'''
+==Human serum transferrin with ferric ion bound at the C-lobe only==
+<StructureSection load='4x1b' size='340' side='right' caption='[[4x1b]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-The entry 4x1b is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4x1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1B FirstGlance]. <br>
-Authors: Wang, M., Zhang, H., Sun, H.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x1d|4x1d]]</td></tr>
-Description: Human serum transferrin with ferric ion bound at the C-lobe only
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x1b RCSB], [http://www.ebi.ac.uk/pdbsum/4x1b PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Sun, H]]
 [[Category: Wang, M]]
 [[Category: Zhang, H]]
-[[Category: Sun, H]]
+[[Category: Ferric]]
+[[Category: Malonate]]
+[[Category: Metal transport]]
+[[Category: Transferrin]]
+[[Category: Ytterbium]]