4mxe: Difference between revisions

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'''Unreleased structure'''
==Human establishment factor-like protein 1==
 
<StructureSection load='4mxe' size='340' side='right' caption='[[4mxe]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
The entry 4mxe is ON HOLD  until Apr 08 2016
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4mxe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MXE FirstGlance]. <br>
Authors: Karlberg, T., Wisniewska, M., Thorsell, A.G., Kouznetsova, E., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kallas, A., Kraulis, P., Kotenyova, T., Moche, M., Nielsen, T.K., Nordlund, P., Nyman, T., Persson, C., Schutz, P., Svensson, L., Tresaugues, L., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mxe RCSB], [http://www.ebi.ac.uk/pdbsum/4mxe PDBsum]</span></td></tr>
Description: Human establishment factor-like protein 1
</table>
[[Category: Unreleased Structures]]
== Function ==
[[Category: Nordlund, P]]
[[http://www.uniprot.org/uniprot/ESCO1_HUMAN ESCO1_HUMAN]] Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.<ref>PMID:14576321</ref> <ref>PMID:15958495</ref> <ref>PMID:18614053</ref> <ref>PMID:19907496</ref> 
[[Category: Johansson, I]]
== References ==
[[Category: Hammarstrom, M]]
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Berg, S Van Den]]
[[Category: Berglund, H]]
[[Category: Bountra, C]]
[[Category: Collins, R]]
[[Category: Collins, R]]
[[Category: Kouznetsova, E]]
[[Category: Edwards, A M]]
[[Category: Flodin, S]]
[[Category: Flores, A]]
[[Category: Graslund, S]]
[[Category: Graslund, S]]
[[Category: Wisniewska, M]]
[[Category: Hammarstrom, M]]
[[Category: Arrowsmith, C.H]]
[[Category: Johansson, I]]
[[Category: Wahlberg, E]]
[[Category: Persson, C]]
[[Category: Berglund, H]]
[[Category: Flores, A]]
[[Category: Van Den Berg, S]]
[[Category: Nyman, T]]
[[Category: Kraulis, P]]
[[Category: Thorsell, A.G]]
[[Category: Schuler, H]]
[[Category: Flodin, S]]
[[Category: Tresaugues, L]]
[[Category: Welin, M]]
[[Category: Edwards, A.M]]
[[Category: Kallas, A]]
[[Category: Kallas, A]]
[[Category: Karlberg, T]]
[[Category: Karlberg, T]]
[[Category: Kotenyova, T]]
[[Category: Kotenyova, T]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Kouznetsova, E]]
[[Category: Kraulis, P]]
[[Category: Moche, M]]
[[Category: Moche, M]]
[[Category: Nielsen, T K]]
[[Category: Nordlund, P]]
[[Category: Nyman, T]]
[[Category: Persson, C]]
[[Category: Structural genomic]]
[[Category: Schuler, H]]
[[Category: Schutz, P]]
[[Category: Svensson, L]]
[[Category: Thorsell, A G]]
[[Category: Tresaugues, L]]
[[Category: Wahlberg, E]]
[[Category: Weigelt, J]]
[[Category: Weigelt, J]]
[[Category: Svensson, L]]
[[Category: Welin, M]]
[[Category: Nielsen, T.K]]
[[Category: Wisniewska, M]]
[[Category: Bountra, C]]
[[Category: Acetyltransferase]]
[[Category: Schutz, P]]
[[Category: Gcn5-related n-acetyltransferase fold]]
[[Category: Nucleus]]
[[Category: Sgc]]
[[Category: Transferase]]

Revision as of 14:12, 8 April 2015

Human establishment factor-like protein 1Human establishment factor-like protein 1

Structural highlights

4mxe is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[ESCO1_HUMAN] Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.[1] [2] [3] [4]

References

  1. ↑ Bellows AM, Kenna MA, Cassimeris L, Skibbens RV. Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains. Nucleic Acids Res. 2003 Nov 1;31(21):6334-43. PMID:14576321
  2. ↑ Hou F, Zou H. Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion. Mol Biol Cell. 2005 Aug;16(8):3908-18. Epub 2005 Jun 15. PMID:15958495 doi:http://dx.doi.org/E04-12-1063
  3. ↑ Zhang J, Shi X, Li Y, Kim BJ, Jia J, Huang Z, Yang T, Fu X, Jung SY, Wang Y, Zhang P, Kim ST, Pan X, Qin J. Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell. 2008 Jul 11;31(1):143-51. doi: 10.1016/j.molcel.2008.06.006. PMID:18614053 doi:http://dx.doi.org/10.1016/j.molcel.2008.06.006
  4. ↑ Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. Cohesin acetylation speeds the replication fork. Nature. 2009 Nov 12;462(7270):231-4. PMID:19907496 doi:nature08550

4mxe, resolution 2.60Å

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