4cv8: Difference between revisions

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-'''Unreleased structure'''
+==MPS1 kinase with 3-aminopyridin-2-one inhibitors==
+<StructureSection load='4cv8' size='340' side='right' caption='[[4cv8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-The entry 4cv8 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4cv8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CV8 FirstGlance]. <br>
-Authors: Fearon, D., Bavetsias, V., Bayliss, R., Schmitt, J., Westwood, I.M., vanMontfort, R.L.M., Jones, K.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3D7:3-AMINO-5-(1-METHYL-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE'>3D7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cv9|4cv9]], [[4cva|4cva]]</td></tr>
-Description: MPS1 kinase with 3-aminopyridin-2-one inhibitors
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cv8 PDBsum]</span></td></tr>
-[[Category: Vanmontfort, R.L.M]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dual-specificity kinase]]
+[[Category: Bavetsias, V]]
+[[Category: Bayliss, R]]
 [[Category: Fearon, D]]
+[[Category: Jones, K]]
 [[Category: Schmitt, J]]
-[[Category: Jones, K]]
+[[Category: Westwood, I M]]
-[[Category: Westwood, I.M]]
+[[Category: VanMontfort, R L.M]]
-[[Category: Bavetsias, V]]
+[[Category: Inhibitor]]
-[[Category: Bayliss, R]]
+[[Category: Transferase]]