Glucocorticoid receptor: Difference between revisions
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*Glucocorticoid receptor LBD domain | *Glucocorticoid receptor LBD domain | ||
**[[1m2z]], [[3cld]], [[3bqd]], [[4lsj]] - hGCR LBD (mutant) + NCOA2 peptide + steroid <br /> | **[[1m2z]], [[3cld]], [[3bqd]], [[4lsj]], [[4p6w]], [[4p6x]] - hGCR LBD (mutant) + NCOA2 peptide + steroid <br /> | ||
**[[3e7c]] - hGCR LBD (mutant) + NCOA2 peptide + non-steroidal agonist<br /> | **[[3e7c]], [[4csj]] - hGCR LBD (mutant) + NCOA2 peptide + non-steroidal agonist<br /> | ||
**[[4mdd]] - hGCR LBD (mutant) + NCOA1 peptide + non-steroidal agonist<br /> | |||
**[[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> | **[[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> | ||
**[[3k22]] - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide<br /> | **[[3k22]] - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide<br /> | ||
Revision as of 12:33, 7 April 2015
Template:STRUCTURE 3g6r Glucocorticoid receptor (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression). GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD); hinge region; ligand-binding domain (LBD) and C terminal domain. GCR interacts with nuclear receptor coactivator 2 (NCOA2) which promotes DNA transcription by acylating histones.
3D structures of glucocorticoid receptor3D structures of glucocorticoid receptor
Updated on 07-April-2015