4w54: Difference between revisions

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'''Unreleased structure'''
==T4 Lysozyme L99A with Ethylbenzene Bound==
 
<StructureSection load='4w54' size='340' side='right' caption='[[4w54]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
The entry 4w54 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4w54]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W54 FirstGlance]. <br>
Authors: Merski, M., Shoichet, B.K., Eidam, O., Fischer, M.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PYJ:PHENYLETHANE'>PYJ</scene></td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
Description: T4 Lysozyme L99A with Ethylbenzene Bound
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w54 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w54 RCSB], [http://www.ebi.ac.uk/pdbsum/4w54 PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4]] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lysozyme]]
[[Category: Eidam, O]]
[[Category: Fischer, M]]
[[Category: Merski, M]]
[[Category: Merski, M]]
[[Category: Fischer, M]]
[[Category: Shoichet, B K]]
[[Category: Shoichet, B.K]]
[[Category: Hydrolase]]
[[Category: Eidam, O]]

Revision as of 16:20, 1 April 2015

T4 Lysozyme L99A with Ethylbenzene BoundT4 Lysozyme L99A with Ethylbenzene Bound

Structural highlights

4w54 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Lysozyme, with EC number 3.2.1.17
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]

References

  1. ↑ Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

4w54, resolution 1.79Å

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OCA
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