Exportin: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
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== Function == | == Function == | ||
'''Exportins''' (XPO) mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus. | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus. | ||
== Disease == | == Disease == | ||
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**[[4bsm]], [[4bsn]] – hXPO – human<br /> | **[[4bsm]], [[4bsn]] – hXPO – human<br /> | ||
**[[1w9c]] – hXPO C terminal 6 heat repeats <br /> | **[[1w9c]] – hXPO C terminal 6 heat repeats <br /> | ||
**[[3vyc]] – yXPO (mutant) - yeast | **[[3vyc]] – yXPO (mutant) - yeast<br /> | ||
**[[4fgv]] – XPO – ''Chaetomium thermophilum''<br /> | |||
*XPO-1 complexes | *XPO-1 complexes | ||
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**[[3gjx]] – hXPO + RNA U transporter 1 + GTPaseRan<br /> | **[[3gjx]] – hXPO + RNA U transporter 1 + GTPaseRan<br /> | ||
**[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]] – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein <br /> | **[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]] – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein <br /> | ||
**[[3wyf]] – yXPO + GTP-binding nuclear protein + Ran-specific GTPase-activating protein <br /> | |||
**[[3wyg]] – yXPO + GTP-binding nuclear protein + PKI-alpha<br /> | |||
**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein + antibiotic<br /> | **[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein + antibiotic<br /> | ||
**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + GTPaseRan - mouse<br /> | **[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + GTPaseRan - mouse<br /> | ||