Sandbox Reserved 1077: Difference between revisions
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==Rv0045c hydrolase from ''M. Tuberculosis''== | ==Rv0045c hydrolase from ''M. Tuberculosis''== | ||
<StructureSection load='3P2M' size='340' side='right' caption='Rv0045c' scene=''> | <StructureSection load='3P2M' size='340' side='right' caption='Rv0045c' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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The <scene name='69/694244/Secondary_structure/1'>secondary structure</scene> of this enzyme is typical of α/β hydrolases | The <scene name='69/694244/Secondary_structure/1'>secondary structure</scene> of this enzyme is typical of α/β hydrolases | ||
The structure solved by x-ray crystallography<ref>PMID:21637775</ref> was missing the <scene name='69/694244/Glu38/1'>N-terminal</scene> 37 residues as well as a <scene name='69/694244/Glu193_and_arg205/3'>flexible loop</scene> (residues 194-204). A theoretical [http://falc-loop.seoklab.org/ FALC-loop] model for this flexible loop is supported by the relative activities of alanine variants of the individual residues 194-204<ref>PMID:25354081</ref>. | The structure solved by x-ray crystallography<ref>PMID:21637775</ref> was missing the <scene name='69/694244/Glu38/1'>N-terminal</scene> 37 residues as well as a <scene name='69/694244/Glu193_and_arg205/3'>flexible loop</scene> (residues 194-204). A theoretical [http://falc-loop.seoklab.org/ FALC-loop]<ref>PMID:21576220</ref> model for this flexible loop is supported by the relative activities of alanine variants of the individual residues 194-204<ref>PMID:25354081</ref>. | ||