4b4c: Difference between revisions
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<StructureSection load='4b4c' size='340' side='right' caption='[[4b4c]], [[Resolution|resolution]] 1.62Å' scene=''> | <StructureSection load='4b4c' size='340' side='right' caption='[[4b4c]], [[Resolution|resolution]] 1.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b4c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4b4c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B4C FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b2t|2b2t]], [[2b2u|2b2u]], [[2b2v|2b2v]], [[2b2w|2b2w]], [[2b2y|2b2y]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b2t|2b2t]], [[2b2u|2b2u]], [[2b2v|2b2v]], [[2b2w|2b2w]], [[2b2y|2b2y]]</td></tr> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: DNA helicase]] | [[Category: DNA helicase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Allerston, C K]] | [[Category: Allerston, C K]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
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[[Category: Carpenter, E P]] | [[Category: Carpenter, E P]] | ||
[[Category: Cooper, C D.O]] | [[Category: Cooper, C D.O]] | ||
[[Category: Delft, F von]] | |||
[[Category: Edwards, A]] | [[Category: Edwards, A]] | ||
[[Category: Gileadi, | [[Category: Gileadi, O]] | ||
[[Category: Shrestha, L]] | [[Category: Shrestha, L]] | ||
[[Category: Vollmar, M]] | [[Category: Vollmar, M]] | ||
Revision as of 11:03, 26 March 2015
Crystal structure of the DNA-binding domain of human CHD1.Crystal structure of the DNA-binding domain of human CHD1.
Structural highlights
Function[CHD1_HUMAN] ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.[1] See AlsoReferences
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