5afp: Difference between revisions

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'''Unreleased structure'''
==Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase peptide from Homo sapiens==
 
<StructureSection load='5afp' size='340' side='right' caption='[[5afp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
The entry 5afp is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5afp]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4uyc 4uyc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AFP FirstGlance]. <br>
Authors: Saleem, M., Karuppiah, V., Pandalaneni, S., Burgoyne, R., Derrick, J.P., Lian, L.Y.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5afp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5afp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5afp RCSB], [http://www.ebi.ac.uk/pdbsum/5afp PDBsum]</span></td></tr>
Description: Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase peptide from Homo sapiens
</table>
[[Category: Unreleased Structures]]
== Disease ==
[[http://www.uniprot.org/uniprot/RK_HUMAN RK_HUMAN]] Oguchi disease;Congenital stationary night blindness. The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
[[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref>  [[http://www.uniprot.org/uniprot/RK_HUMAN RK_HUMAN]] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.<ref>PMID:15946941</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Burgoyne, R]]
[[Category: Derrick, J P]]
[[Category: Karuppiah, V]]
[[Category: Karuppiah, V]]
[[Category: Lian, L Y]]
[[Category: Pandalaneni, S]]
[[Category: Pandalaneni, S]]
[[Category: Lian, L.Y]]
[[Category: Saleem, M]]
[[Category: Saleem, M]]
[[Category: Burgoyne, R]]
[[Category: Signaling protein]]
[[Category: Derrick, J.P]]

Revision as of 14:57, 18 March 2015

Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase peptide from Homo sapiensNeuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase peptide from Homo sapiens

Structural highlights

5afp is a 4 chain structure. This structure supersedes the now removed PDB entry 4uyc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[RK_HUMAN] Oguchi disease;Congenital stationary night blindness. The disease is caused by mutations affecting the gene represented in this entry.

Function

[NCS1_RAT] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.[1] [RK_HUMAN] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.[2]

References

  1. ↑ Gambino F, Pavlowsky A, Begle A, Dupont JL, Bahi N, Courjaret R, Gardette R, Hadjkacem H, Skala H, Poulain B, Chelly J, Vitale N, Humeau Y. IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9063-8. Epub 2007 May 14. PMID:17502602 doi:http://dx.doi.org/10.1073/pnas.0701133104
  2. ↑ Horner TJ, Osawa S, Schaller MD, Weiss ER. Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities. J Biol Chem. 2005 Aug 5;280(31):28241-50. Epub 2005 Jun 9. PMID:15946941 doi:http://dx.doi.org/10.1074/jbc.M505117200

5afp, resolution 2.30Å

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