2my1: Difference between revisions
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''' | ==Solution structure of Bud31p== | ||
<StructureSection load='2my1' size='340' side='right' caption='[[2my1]], [[NMR_Ensembles_of_Models | 35 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2my1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MY1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MY1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2my1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2my1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2my1 RCSB], [http://www.ebi.ac.uk/pdbsum/2my1 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BUD31_YEAST BUD31_YEAST]] Involved in pre-mRNA splicing. Important for bud site selection. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Establishing the binding topology of structural zinc ions in proteins is an essential part of their structure determination by NMR spectroscopy. Using 113 Cd NMR experiments with 113 Cd-substituted samples is a useful approach but has previously been limited mainly to very small protein domains. Here we used 113 Cd NMR spectroscopy during structure determination of Bud31p, a 157-residue yeast protein containing an unusual Zn3 Cys9 cluster, demonstrating that recent hardware developments make this approach feasible for significantly larger systems. | |||
Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.,van Roon AM, Yang JC, Mathieu D, Bermel W, Nagai K, Neuhaus D Angew Chem Int Ed Engl. 2015 Feb 20. doi: 10.1002/anie.201412210. PMID:25703931<ref>PMID:25703931</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bermel, W]] | |||
[[Category: Mathieu, D]] | [[Category: Mathieu, D]] | ||
[[Category: Nagai, K]] | [[Category: Nagai, K]] | ||
[[Category: | [[Category: Neuhaus, D]] | ||
[[Category: Roon, A M.van]] | |||
[[Category: Yang, J]] | [[Category: Yang, J]] | ||
[[Category: | [[Category: Splicing]] | ||
[[Category: | [[Category: Splicing protein]] | ||
[[Category: Zinc cluster]] | |||
[[Category: Zinc finger]] | |||
Revision as of 14:49, 11 March 2015
Solution structure of Bud31pSolution structure of Bud31p
Structural highlights
Function[BUD31_YEAST] Involved in pre-mRNA splicing. Important for bud site selection. Publication Abstract from PubMedEstablishing the binding topology of structural zinc ions in proteins is an essential part of their structure determination by NMR spectroscopy. Using 113 Cd NMR experiments with 113 Cd-substituted samples is a useful approach but has previously been limited mainly to very small protein domains. Here we used 113 Cd NMR spectroscopy during structure determination of Bud31p, a 157-residue yeast protein containing an unusual Zn3 Cys9 cluster, demonstrating that recent hardware developments make this approach feasible for significantly larger systems. Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.,van Roon AM, Yang JC, Mathieu D, Bermel W, Nagai K, Neuhaus D Angew Chem Int Ed Engl. 2015 Feb 20. doi: 10.1002/anie.201412210. PMID:25703931[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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