Calpain: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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**[[1aj5]]– rCAP domain VI – rat<br /> | **[[1aj5]]– rCAP domain VI – rat<br /> | ||
**[[1dvi]] - rCAP domain VI + Ca<br /> | |||
**[[1np8]] – rCAP residues 87-245 - Cd<br /> | **[[1np8]] – rCAP residues 87-245 - Cd<br /> | ||
**[[1alv]], [[1nx2]] - pCAP domain VI + Ca – pig<br /> | **[[1alv]], [[1nx2]] - pCAP domain VI + Ca – pig<br /> | ||
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**[[1nx0]] - pCAP domain VI + Ca+ Calpastatin peptide + small molecule inhibitor peptide<br /> | **[[1nx0]] - pCAP domain VI + Ca+ Calpastatin peptide + small molecule inhibitor peptide<br /> | ||
**[[1nx1]] - pCAP domain VI + Ca+ Calpastatin peptide<br /> | **[[1nx1]] - pCAP domain VI + Ca+ Calpastatin peptide<br /> | ||
**[[4phj]] – hCAP EF-hand subunit + Ca - human<br /> | |||
**[[4phk]], [[4phm]], [[4phn]] – hCAP EF-hand subunit + Ca + inhibitor<br /> | |||
*CAP1 | *CAP1 | ||
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**[[1tl9]] - rCAP protease domain + Ca+ leupeptin inhibitor<br /> | **[[1tl9]] - rCAP protease domain + Ca+ leupeptin inhibitor<br /> | ||
**[[2g8e]], [[2g8j]], [[2nqg]], [[2nqi]], [[2r9c]], [[2r9f]] - rCAP protease domain + Ca+ inhibitor<br /> | **[[2g8e]], [[2g8j]], [[2nqg]], [[2nqi]], [[2r9c]], [[2r9f]] - rCAP protease domain + Ca+ inhibitor<br /> | ||
**[[2ary]] - hCAP protease domain + Ca | **[[2ary]] - hCAP protease domain + Ca <br /> | ||
**[[1zcm]] - hCAP protease domain (mutant) + Ca+ inhibitor<br /> | **[[1zcm]] - hCAP protease domain (mutant) + Ca+ inhibitor<br /> | ||
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**[[3bow]] - rCAP small subunit + rCAP2 large subunit + Calpastatin + Ca<br /> | **[[3bow]] - rCAP small subunit + rCAP2 large subunit + Calpastatin + Ca<br /> | ||
**[[1kfu]], [[1kfx]] – hCAP small subunit + hCAP2 large subunit | **[[1kfu]], [[1kfx]] – hCAP small subunit + hCAP2 large subunit | ||
*CAP3 | |||
**[[4okh]] - hCAP EF-hand domain<br /> | |||
*CAP7 | *CAP7 | ||
Revision as of 14:44, 9 March 2015
Calpains (CAP) are calcium-dependent cysteine proteases. The CAP family contains 14 members. CAP is a heterodimer containing a small28kDa regulatory subunit which is identical for all CAPs and a large 80kDa catalytic subunit. The best characterized CAPs are CAP1 (or mu-CAP) and CAP2 (or M-CAP). CAP7 is atypical CAP that lacks a penta-EF-hand domain. CAP8 and CAP9 are involved in the mucosal defense against stress-induced gastropathies. CAP9 has been identified as the tumor suppressor for gastric cancer. CAP13 is expressed in testis and lungs. CAPs are regulated by Ca+2 concentration, phosphorylation and calpastatin. |
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3D structures of calpain3D structures of calpain
Updated on 09-March-2015