2qk8: Difference between revisions

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[[Image:2qk8.jpg|left|200px]]<br /><applet load="2qk8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2qk8.jpg|left|200px]]
caption="2qk8, resolution 2.40&Aring;" />
 
'''Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase'''<br />
{{Structure
|PDB= 2qk8 |SIZE=350|CAPTION= <scene name='initialview01'>2qk8</scene>, resolution 2.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE= dfrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
}}
 
'''Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2QK8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with <scene name='pdbligand=MTX:'>MTX</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK8 OCA].  
2QK8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QK8 OCA].  


==Reference==
==Reference==
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase., Bennett BC, Xu H, Simmerman RF, Lee RE, Dealwis CG, J Med Chem. 2007 Sep 6;50(18):4374-81. Epub 2007 Aug 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17696333 17696333]
Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase., Bennett BC, Xu H, Simmerman RF, Lee RE, Dealwis CG, J Med Chem. 2007 Sep 6;50(18):4374-81. Epub 2007 Aug 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17696333 17696333]
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
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[[Category: pteridine binding]]
[[Category: pteridine binding]]


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