4qs9: Difference between revisions

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'''Unreleased structure'''
==Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form==
 
<StructureSection load='4qs9' size='340' side='right' caption='[[4qs9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
The entry 4qs9 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4qs9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QS9 FirstGlance]. <br>
Authors: Feng, J., Zhao, S., Liu, L.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qs7|4qs7]], [[4qs8|4qs8]]</td></tr>
Description: Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qs9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qs9 RCSB], [http://www.ebi.ac.uk/pdbsum/4qs9 PDBsum]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HXK1_ARATH HXK1_ARATH]] Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells.<ref>PMID:12690200</ref> <ref>PMID:16920781</ref> <ref>PMID:9014361</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Hexokinase]]
[[Category: Feng, J]]
[[Category: Feng, J]]
[[Category: Liu, L]]
[[Category: Liu, L]]
[[Category: Zhao, S]]
[[Category: Zhao, S]]
[[Category: Atp-dependent]]
[[Category: Sugar sensor]]
[[Category: Transferase]]

Revision as of 14:59, 12 February 2015

Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound formArabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form

Structural highlights

4qs9 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:Hexokinase, with EC number 2.7.1.1
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[HXK1_ARATH] Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells.[1] [2] [3]

References

  1. ↑ Moore B, Zhou L, Rolland F, Hall Q, Cheng WH, Liu YX, Hwang I, Jones T, Sheen J. Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling. Science. 2003 Apr 11;300(5617):332-6. PMID:12690200 doi:http://dx.doi.org/10.1126/science.1080585
  2. ↑ Kim M, Lim JH, Ahn CS, Park K, Kim GT, Kim WT, Pai HS. Mitochondria-associated hexokinases play a role in the control of programmed cell death in Nicotiana benthamiana. Plant Cell. 2006 Sep;18(9):2341-55. Epub 2006 Aug 18. PMID:16920781 doi:http://dx.doi.org/10.1105/tpc.106.041509
  3. ↑ Jang JC, Leon P, Zhou L, Sheen J. Hexokinase as a sugar sensor in higher plants. Plant Cell. 1997 Jan;9(1):5-19. PMID:9014361 doi:http://dx.doi.org/10.1105/tpc.9.1.5

4qs9, resolution 2.10Å

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