3wpe: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
''' | ==Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer== | ||
<StructureSection load='3wpe' size='340' side='right' caption='[[3wpe]], [[Resolution|resolution]] 2.38Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3wpe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WPE FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wpb|3wpb]], [[3wpc|3wpc]], [[3wpd|3wpd]], [[3wpf|3wpf]], [[3wpg|3wpg]], [[3wph|3wph]], [[3wpi|3wpi]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wpe RCSB], [http://www.ebi.ac.uk/pdbsum/3wpe PDBsum]</span></td></tr> | |||
</table> | |||
[[ | == Function == | ||
[[ | [[http://www.uniprot.org/uniprot/TLR9_BOVIN TLR9_BOVIN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ohto, U]] | [[Category: Ohto, U]] | ||
[[Category: Shimizu, T]] | [[Category: Shimizu, T]] | ||
[[Category: Tanji, H]] | |||
[[Category: Dna binding]] | |||
[[Category: Dna binding protein-dna complex]] | |||
[[Category: Glycosylation]] | |||
[[Category: Innate immunity]] | |||
[[Category: Leucine rich repeat]] | |||
[[Category: Receptor]] | |||
Revision as of 14:55, 12 February 2015
Crystal structure of bovine TLR9 in complex with agonistic DNA1668_12merCrystal structure of bovine TLR9 in complex with agonistic DNA1668_12mer
Structural highlights
Function[TLR9_BOVIN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). |
| ||||||||||||||||