4liz: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4liz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4liz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4liz RCSB], [http://www.ebi.ac.uk/pdbsum/4liz PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4liz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4liz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4liz RCSB], [http://www.ebi.ac.uk/pdbsum/4liz PDBsum]</span></td></tr> | ||
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== Publication Abstract from PubMed == | |||
Entamoeba histolytica is a protist parasite that is the causative agent of amoebiasis, and is a highly motile organism. The motility is essential for its survival and pathogenesis, and a dynamic actin cytoskeleton is required for this process. EhCoactosin, an actin-binding protein of the ADF/cofilin family, participates in actin dynamics, and here we report our studies of this protein using both structural and functional approaches. The X-ray crystal structure of EhCoactosin resembles that of human coactosin-like protein, with major differences in the distribution of surface charges and the orientation of terminal regions. According to in vitro binding assays, full-length EhCoactosin binds both F- and G-actin. Instead of acting to depolymerize or severe F-actin, EhCoactosin directly stabilizes the polymer. When EhCoactosin was visualized in E. histolytica cells using either confocal imaging or total internal reflectance microscopy, it was found to colocalize with F-actin at phagocytic cups. Over-expression of this protein stabilized F-actin and inhibited the phagocytic process. EhCoactosin appears to be an unusual type of coactosin involved in E. histolytica actin dynamics. | |||
EhCoactosin stabilizes actin filaments in the protist parasite Entamoeba histolytica.,Kumar N, Somlata, Mazumder M, Dutta P, Maiti S, Gourinath S PLoS Pathog. 2014 Sep 11;10(9):e1004362. doi: 10.1371/journal.ppat.1004362., eCollection 2014 Sep. PMID:25210743<ref>PMID:25210743</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | |||
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