4cvh: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of human isoprenoid synthase domain-containing protein==
+<StructureSection load='4cvh' size='340' side='right' caption='[[4cvh]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
-The entry 4cvh is ON HOLD  until Mar 27 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4cvh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CVH FirstGlance]. <br>
-Authors: Kopec, J., Froese, D.S., Krojer, T., Newman, J., Kiyani, W., Goubin, S., Strain-Damerell, C., Vollmar, M., von Delft, F., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Lefeber, D.J., Yue, W.W.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cvh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cvh RCSB], [http://www.ebi.ac.uk/pdbsum/4cvh PDBsum]</span></td></tr>
-Description: Crystal structure of human isoprenoid synthase domain-containing protein
+</table>
-[[Category: Unreleased Structures]]
+== Disease ==
-[[Category: Lefeber, D.J]]
+[[http://www.uniprot.org/uniprot/ISPD_HUMAN ISPD_HUMAN]] Autosomal recessive limb-girdle muscular dystrophy due to ISPD deficiency;Congenital muscular dystrophy without intellectual disability;Walker-Warburg syndrome. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/ISPD_HUMAN ISPD_HUMAN]] Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation.<ref>PMID:22522420</ref> <ref>PMID:22522421</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arrowsmith, C]]
+[[Category: Bountra, C]]
+[[Category: Burgess-Brown, N]]
+[[Category: Delft, F von]]
+[[Category: Edwards, A]]
+[[Category: Froese, D S]]
 [[Category: Goubin, S]]
-[[Category: Burgess-Brown, N]]
-[[Category: Yue, W.W]]
 [[Category: Kiyani, W]]
 [[Category: Kopec, J]]
-[[Category: Von Delft, F]]
+[[Category: Krojer, T]]
-[[Category: Arrowsmith, C]]
+[[Category: Lefeber, D J]]
 [[Category: Newman, J]]
-[[Category: Froese, D.S]]
-[[Category: Edwards, A]]
 [[Category: Strain-Damerell, C]]
-[[Category: Krojer, T]]
-[[Category: Bountra, C]]
 [[Category: Vollmar, M]]
+[[Category: Yue, W W]]
+[[Category: Transferase]]