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''' | ==SorLA Vps10p domain in ligand-free form== | ||
<StructureSection load='3wsx' size='340' side='right' caption='[[3wsx]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3wsx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WSX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wsy|3wsy]], [[3wsz|3wsz]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wsx RCSB], [http://www.ebi.ac.uk/pdbsum/3wsx PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kitago, Y]] | |||
[[Category: Nagae, M]] | |||
[[Category: Nakata, Z]] | |||
[[Category: Nogi, T]] | [[Category: Nogi, T]] | ||
[[Category: Takagi, J]] | [[Category: Takagi, J]] | ||
[[Category: | [[Category: Beta-propeller]] | ||
[[Category: | [[Category: Protein binding]] | ||
[[Category: | [[Category: Receptor]] | ||
Revision as of 18:53, 7 February 2015
SorLA Vps10p domain in ligand-free formSorLA Vps10p domain in ligand-free form
Structural highlights
Function[SORL_HUMAN] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. |
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