4res: Difference between revisions
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''' | ==Crystal structure of the Na,K-ATPase E2P-bufalin complex with bound potassium== | ||
<StructureSection load='4res' size='340' side='right' caption='[[4res]], [[Resolution|resolution]] 3.41Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4res]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3n2f 3n2f]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RES FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=17F:O-[(S)-({(2R)-2,3-BIS[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL}OXY)(HYDROXY)PHOSPHORYL]-L-SERINE'>17F</scene>, <scene name='pdbligand=BUF:BUFALIN'>BUF</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hyt|4hyt]], [[3n23|3n23]], [[4ret|4ret]]</td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4res FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4res OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4res RCSB], [http://www.ebi.ac.uk/pdbsum/4res PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG]] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [[http://www.uniprot.org/uniprot/AT1B1_PIG AT1B1_PIG]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Sodium/potassium-exchanging ATPase]] | |||
[[Category: Sus scrofa]] | |||
[[Category: Fedosova, N U]] | |||
[[Category: Gregersen, J L]] | |||
[[Category: Laursen, M]] | [[Category: Laursen, M]] | ||
[[Category: Nissen, P]] | [[Category: Nissen, P]] | ||
[[Category: Yatime, L]] | [[Category: Yatime, L]] | ||
[[Category: Alpha-helical transmembrane protein]] | |||
[[Category: Atp binding]] | |||
[[Category: Atpase]] | |||
[[Category: Glycosylation]] | |||
[[Category: Hydrolase-inhibitor complex]] | |||
[[Category: Membrane protein]] | |||
[[Category: Multisubunit complex]] | |||
[[Category: Phosphorylation]] | |||
[[Category: Plasma membrane]] | |||
[[Category: Potassium binding]] | |||
[[Category: Potassium ion transport]] | |||
[[Category: Receptor for cardiotonic steroid]] | |||
[[Category: Sodium binding]] | |||
[[Category: Sodium ion transport]] | |||
[[Category: Trimeric complex]] | |||