3n7l: Difference between revisions
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<StructureSection load='3n7l' size='340' side='right' caption='[[3n7l]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3n7l' size='340' side='right' caption='[[3n7l]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3n7l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3n7l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7L FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n7j|3n7j]], [[3n7k|3n7k]], [[3n7m|3n7m]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n7j|3n7j]], [[3n7k|3n7k]], [[3n7m|3n7m]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Clostridium Botulinum ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Clostridium Botulinum ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7l RCSB], [http://www.ebi.ac.uk/pdbsum/3n7l PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7l RCSB], [http://www.ebi.ac.uk/pdbsum/3n7l PDBsum]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bacillus botulinus van ermengem 1896]] | ||
[[Category: Baldwin, M R]] | [[Category: Baldwin, M R]] | ||
[[Category: Barbieri, J T]] | [[Category: Barbieri, J T]] | ||
[[Category: Fu, Z]] | [[Category: Fu, Z]] | ||
[[Category: Karalewitz, A]] | [[Category: Karalewitz, A]] | ||
[[Category: Kim, J | [[Category: Kim, J J.P]] | ||
[[Category: Kroken, A]] | [[Category: Kroken, A]] | ||
[[Category: Botulinum neurotoxin]] | [[Category: Botulinum neurotoxin]] | ||
Revision as of 14:05, 28 January 2015
Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domainCrystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A-G) based on a lack of cross antiserum neutralization. BoNTs utilize gangliosides as components of the host receptors for binding and entry into neurons. Members of BoNT/C and BoNT/D serotypes include mosaic toxins that are organized in D/C and C/D toxins. One D/C mosaic toxin, BoNT/D-South Africa (BoNT/D-SA), was not fully neutralized by immunization with BoNT serotype C or D, which stimulated this study. Here the crystal structures of the receptor binding domains of BoNT/C, BoNT/D, and BoNT/D-SA are presented. Biochemical and cell binding studies show that BoNT/C and BoNT/D-SA possess unique mechanisms for ganglioside binding. These studies provide new information about how the BoNTs can enter host cells as well as a basis for understanding the immunological diversity of these neurotoxins. Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA .,Karalewitz AP, Kroken AR, Fu Z, Baldwin MR, Kim JJ, Barbieri JT Biochemistry. 2010 Aug 23. PMID:20731382[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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