Human ABO(H) Blood Group Glycosyltransferases: Difference between revisions
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== Reaction == | == Reaction == | ||
== Genetics == | == Genetics == | ||
The ABO gene locus expressing the glycosyltransferases has three main alleleic forms: A, B, and O, the A allele encodes GTA. The B allele encodes GTB, the O allele differs slightly from the A allele by deletion of a single nucleotide. The deletion causes a frameshift and results in translation of an almost entirely different protein that lacks enzymatic activity. This results in H antigen remaining unchanged in case of O groups. | |||
== Structural highlights == | == Structural highlights == | ||