Binding site of AChR: Difference between revisions
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== Function of Acetylcholine receptor == | == Function of Acetylcholine receptor == | ||
The α-Neurotoxins such as [http://en.wikipedia.org/wiki/Alpha-Bungarotoxin α-bungarotoxin] (α-BTX)can compete antagonists of acetylcholine for its site. So | The α-Neurotoxins such as [http://en.wikipedia.org/wiki/Alpha-Bungarotoxin α-bungarotoxin] (α-BTX)can compete antagonists of acetylcholine for its site. So studying the binding site of AChR is very important for the development of antidotesagainstα-BTX poisoning as well as drugs against, like [http://en.wikipedia.org/wiki/Alzheimer's_disease Alzheimer's disease] and [http://en.wikipedia.org/wiki/Nicotine nicotine addiction]. | ||
The X-ray structure of AChR has not yet been solved since its hydrophobic character hampers its successful crystallization. So in this page,<ref>PMID:11683996</ref> We will use a complex of α-bungarotoxinwith a high affinity 13-residue peptide that is homologous to the αsubunit of AChR to study the AChR binding site in general. We also will present the [http://proteopedia.org/wiki/index.php/Acetylcholine_binding_protein Acetylcholine binding protein] and the general [http://proteopedia.org/wiki/index.php/4hfi pentameric ligand gated ion channels] to help you understand this kind of structure and their function. | The X-ray structure of AChR has not yet been solved since its hydrophobic character hampers its successful crystallization. So in this page,<ref>PMID:11683996</ref> We will use a complex of α-bungarotoxinwith a high affinity 13-residue peptide that is homologous to the αsubunit of AChR to study the AChR binding site in general. We also will present the [http://proteopedia.org/wiki/index.php/Acetylcholine_binding_protein Acetylcholine binding protein] and the general [http://proteopedia.org/wiki/index.php/4hfi pentameric ligand gated ion channels] to help you understand this kind of structure and their function. | ||