4cbm: Difference between revisions
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''' | ==Pestivirus NS3 helicase== | ||
<StructureSection load='4cbm' size='340' side='right' caption='[[4cbm]], [[Resolution|resolution]] 3.27Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4cbm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CBM FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cbg|4cbg]], [[4cbh|4cbh]], [[4cbi|4cbi]], [[4cbl|4cbl]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cbm RCSB], [http://www.ebi.ac.uk/pdbsum/4cbm PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA]] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bricogne, G]] | |||
[[Category: Duquerroy, S]] | |||
[[Category: Kwok, J]] | |||
[[Category: Lamp, B]] | [[Category: Lamp, B]] | ||
[[Category: Perez, J]] | |||
[[Category: Rey, F A]] | |||
[[Category: Rumenapf, T]] | |||
[[Category: Tortorici, M A]] | |||
[[Category: Vachette, P]] | [[Category: Vachette, P]] | ||
[[Category: Vonrhein, C]] | [[Category: Vonrhein, C]] | ||
[[Category: | [[Category: Flaviviridae ns3]] | ||
[[Category: | [[Category: Hydrolase]] | ||
[[Category: | [[Category: Sax]] | ||
[[Category: | [[Category: Sf2 helicase]] | ||
Revision as of 19:55, 21 January 2015
Pestivirus NS3 helicasePestivirus NS3 helicase
Structural highlights
Function[POLG_CSFVA] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539] |
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