2qfc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2qfc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis_serovar_israelensis_atcc_35646 Bacillus thuringiensis serovar israelensis atcc 35646]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QFC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2qfc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis_serovar_israelensis_atcc_35646 Bacillus thuringiensis serovar israelensis atcc 35646]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QFC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">plcR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339854 Bacillus thuringiensis serovar israelensis ATCC 35646])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">plcR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=339854 Bacillus thuringiensis serovar israelensis ATCC 35646])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qfc RCSB], [http://www.ebi.ac.uk/pdbsum/2qfc PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qfc RCSB], [http://www.ebi.ac.uk/pdbsum/2qfc PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bacillus thuringiensis serovar israelensis atcc 35646]] | [[Category: Bacillus thuringiensis serovar israelensis atcc 35646]] | ||
[[Category: Arold, S T | [[Category: Arold, S T]] | ||
[[Category: Chaix, D | [[Category: Chaix, D]] | ||
[[Category: Declerck, N | [[Category: Declerck, N]] | ||
[[Category: Hoh, F | [[Category: Hoh, F]] | ||
[[Category: Rugani, N | [[Category: Rugani, N]] | ||
[[Category: Hth]] | [[Category: Hth]] | ||
[[Category: Tpr]] | [[Category: Tpr]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
Revision as of 21:41, 19 January 2015
Crystal Structure of Bacillus thuringiensis PlcR complexed with PapRCrystal Structure of Bacillus thuringiensis PlcR complexed with PapR
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedGram-positive bacteria use a wealth of extracellular signaling peptides, so-called autoinducers, to regulate gene expression according to population densities. These "quorum sensing" systems control vital processes such as virulence, sporulation, and gene transfer. Using x-ray analysis, we determined the structure of PlcR, the major virulence regulator of the Bacillus cereus group, and obtained mechanistic insights into the effects of autoinducer binding. Our structural and phylogenetic analysis further suggests that all of those quorum sensors that bind directly to their autoinducer peptide derive from a common ancestor and form a single family (the RNPP family, for Rap/NprR/PlcR/PrgX) with conserved features. As a consequence, fundamentally different processes in different bacterial genera appear regulated by essentially the same autoinducer recognition mechanism. Our results shed light on virulence control by PlcR and elucidate origin and evolution of multicellular behavior in bacteria. Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria.,Declerck N, Bouillaut L, Chaix D, Rugani N, Slamti L, Hoh F, Lereclus D, Arold ST Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18490-5. Epub 2007 Nov 12. PMID:17998541[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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