2pbx: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2pbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PBX FirstGlance]. <br> | <table><tr><td colspan='2'>[[2pbx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PBX FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pbx RCSB], [http://www.ebi.ac.uk/pdbsum/2pbx PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pbx RCSB], [http://www.ebi.ac.uk/pdbsum/2pbx PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Vibrio cholerae]] | [[Category: Vibrio cholerae]] | ||
[[Category: DeSilva, R S | [[Category: DeSilva, R S]] | ||
[[Category: Kovacikova, G | [[Category: Kovacikova, G]] | ||
[[Category: Kull, F J | [[Category: Kull, F J]] | ||
[[Category: Lin, W | [[Category: Lin, W]] | ||
[[Category: Skorupski, K | [[Category: Skorupski, K]] | ||
[[Category: Taylor, R K | [[Category: Taylor, R K]] | ||
[[Category: Dna-binding]] | [[Category: Dna-binding]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
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[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
Revision as of 19:59, 19 January 2015
Vibrio cholerae HapRVibrio cholerae HapR
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedQuorum sensing in Vibrio cholerae involves signaling between two-component sensor protein kinases and the response regulator LuxO to control the expression of the master regulator HapR. HapR, in turn, plays a central role in regulating a number of important processes, such as virulence gene expression and biofilm formation. We have determined the crystal structure of HapR to 2.2-A resolution. Its structure reveals a dimeric, two-domain molecule with an all-helical structure that is strongly conserved with members of the TetR family of transcriptional regulators. The N-terminal DNA-binding domain contains a helix-turn-helix DNA-binding motif and alteration of certain residues in this domain completely abolishes the ability of HapR to bind to DNA, alleviating repression of both virulence gene expression and biofilm formation. The C-terminal dimerization domain contains a unique solvent accessible tunnel connected to an amphipathic cavity, which by analogy with other TetR regulators, may serve as a binding pocket for an as-yet-unidentified ligand. Crystal structure of the Vibrio cholerae quorum-sensing regulatory protein HapR.,De Silva RS, Kovacikova G, Lin W, Taylor RK, Skorupski K, Kull FJ J Bacteriol. 2007 Aug;189(15):5683-91. Epub 2007 May 25. PMID:17526705[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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